A suicide bombing killed 48 people, among them women and children, Wednesday in northern Syria, the UK-based Syrian Observatory for Human Rights said.
A truck bomb exploded near buildings belonging to a Kurdish security agency and other governmental departments in the city of Qamishli near the border with Turkey, CNN reports.
The observatory said 140 people were hurt.
ISIS claimed responsibility and said one of its members drove a truck rigged with explosives to reach the Kurdish administrative complex where defense, interior and military recruiting departments operated. Kurdish officials are trying to learn how ISIS was able to get so much explosives into their stronghold.
ISIS said the suicide operation was a "response to the crimes committed by the coalition warplanes against the vulnerable people of men, women and children in Manbij City."
Human rights groups said last week that U.S.-led airstrikes in and around the ISIS-controlled city of Manbij have killed more than 100 and wounded dozens more since June.
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