Tackling drugs and reducing trade barriers topped the agenda when President Barack Obama hosted talks with the leaders of Canada and Mexico.
Obama said the three nations would "simplify and eliminate" more trading regulations to boost their economies.
He said 2011 saw US trade with its two neighbours top $1tn for the first time.
Mexican President Felipe Calderon called on the US to do more to stop US-made assault weapons fuelling his country's drugs war.
The meeting comes two weeks before a broader regional summit - the Summit of the Americas - in Cartagena, Colombia.