Luis Suarez left England on the brink of a World Cup exit as his double strike gave Uruguay victory in Sao Paulo.
Liverpool striker Suarez was making his return after a month out following knee surgery - and it proved to be bad timing for England and manager Roy Hodgson as his brilliance was the difference in a fiercely-fought encounter.
Suarez put Uruguay ahead with a first-half header then scored a superb winner six minutes from time after Wayne Rooney's first goal at a World Cup gave England hope of avoiding a second successive Group D loss.
But defeat means the odds are now stacked against England escaping this tough group.
They will be out unless Italy - who overcame England in Manaus - beat Costa Rica today.