In a weekend interview on live television, Oxford-educated Khan said an increase in rapes indicated the “consequences in any society where vulgarity is on the rise”.
Human rights groups in Pakistan have accused Prime Minister Imran Khan of being a "rape apologist" after he blamed a rise in sexual assault cases on how women dress.
During a live television interview, he advised women to cover up to prevent temptation.
He added "in any society where vulgarity is prevalent, there are consequences."
Hundreds have signed a statement circulating online on Wednesday, calling Khan’s comments “factually incorrect, insensitive and dangerous”.
“Fault rests solely with the rapist and the system that enables the rapist, including a culture fostered by statements such as those made by [Khan],” the statement said.
People have also signed a statement demanding an apology.
The Human Rights Commission of Pakistan, an independent rights watchdog, on Tuesday said it was “appalled” by the comments.
“Not only does this betray a baffling ignorance of where, why and how rape occurs, but it also lays the blame on rape survivors, who, as the government must know, can range from young children to victims of honour crimes,” it said.
Pakistan is a deeply conservative country where victims of sexual abuse are often viewed with suspicion and criminal complaints are rarely investigated seriously.
Much of the country lives under an “honour” code where women who bring “shame” on the family can be subjected to violence or murder.
Pakistan regularly ranks among the worst places in the world for gender equality