At 11:58 pm, Union Health Minister Mansukh Mandaviya tweeted to confirm the "historic" figure.
Earlier, the Prime Minister took to Twitter to declare that "every Indian would be proud of today's record vaccination numbers" and thank healthcare and frontline workers who had worked hard to make the vaccination drive a success.
The government's tracker showed around 800 vaccinations per second, or around 48,000 in a minute, National Health Authority chief RS Sharma told NDTV in the evening as he called Friday "a historic day" and praised health workers across the country for their resilience.
Top government expert Dr NK Arora said that the record number of jabs administered on Friday were the result of "months of sustained efforts".
"We went from a few thousand to two crore vaccines doses administered in one day. Social mobilisation was key," Dr Arora said, as he praised the media for playing a role in the effort.
AIIMS (Delhi) chief Dr Randeep Guleria told NDTV that it was imperative to sustain this surge in vaccination numbers; as of Friday morning over 1.2 crore doses needed to be administered per day to reach the target of giving two doses to at least 60 per cent of the population by end-December.